MelaTrepein 5000

MelaTrepein 5000– an Epigenetic Whitening enhancer

MelaTrepein 5000 is the latest INCOSPHARM Autophagy ingredient aimed at targeting skin hyperpigmentation

It is present at 0.5% in an aqueous solution

MelaTrepein 5000 is a new peptide for skin whitening / brightening

MelaTrepein 5000 is a safe and effective treatment of Solar lentigo or Age Spots. Solar lentigo are harmless patches of darkened skin, resulting from exposure to UV radiation, which causes local proliferation of melanocytes and accumulation of melanin within keratinocytes). Solar lentigos or lentigines are common, especially in people over the age of 40 years.

MelaTrepein 5000 prevents disruption of  the DEJ (Demal-Epidermal-Junction), and Melanin accumulation in the Dermis

MelaTrepein 5000 combats the accumulation of Lipofuscin – the fine yellow-brown pigment granules composed of lipid-containing residues of lysosomal digestion. Lipofuscin is considered to be one of the aging or “wear-and-tear” pigments, found in the liver, kidney, heart muscle, retina, nerve cells, and the skin

MelaTrepein 5000 is a dual targeting active ingredient for Hyperpigmentation

The principle components are:

Pentasodium Tetracarboxymethyl Acetylhydroxyprolyl Dipeptide-12, which activates autophagy in keratinocytes and degrades existing melanosomes

Pentasodium Tetracarboxymethyl Dipeptide-51, which induces the inhibition of PAR-2 in keratinocytes preventing new melanosomes from entering the keratinocytes

MelaTrepein 5000 does not affect Melanogenesis of Melanocytes (MITF, Tyrosinase)

FULL INCI:  Water, 1,2 Hexanediol, Pentasodium tetracarboxymethyl dipeptide-51, Pentasodium Tetracarboxymethyl Acetylhydroxyprolyl Dipeptide-12