Introducing HydroHA (800Da): The Next Generation of Hyaluronic Acid
At Unifect Ltd, we pride ourselves on staying ahead of the curve when it comes to innovative cosmetic ingredients. Today, we’re proud to introduce HydroHA (800Da) — an ultra-low molecular weight hyaluronic acid that sets a new standard for efficacy, cellular penetration, and skin rejuvenation.
As the market evolves, so too must our solutions. Consumers no longer seek hydration alone; the demand has shifted to anti-aging, soothing, and textural improvement. HydroHA rises to this challenge with a scientifically validated mechanism of action and unrivalled performance compared to traditional HA variants.
Why Molecular Weight Matters — And Why 800Da Is Game-Changing
The molecular weight of hyaluronic acid determines how deep it can penetrate the skin. While conventional high molecular weight HA (HMW-HA) is great for surface hydration, it struggles to move past the epidermis.
HydroHA, with its ultra-low molecular weight of 800 Daltons, is engineered to go deeper. This allows it to:
-
Reach the dermal layers, not just sit on the surface
-
Interact directly with cell receptors like CD44 for targeted efficacy
-
Deliver profound hydration and visible results from within
Compared to competitive products in the low-MW category, HydroHA exhibits superior cellular uptake, enhanced anti-inflammatory response, and clinically significant anti-aging performance.
Triple-Core Rejuvenation: The Science Behind the Benefits
HydroHA isn’t just about size—it’s about smart molecular design. Developed through pioneering biotechnology, including the use of class II hyaluronidase genes and synthetic bioengineering in Pichia pastoris, HydroHA is supported by 25 patents and 15 peer-reviewed papers.
Its triple-action rejuvenation effect includes:
Mitochondrial Repair
At just 0.05%, HydroHA improves mitochondrial integrity by 66%, supporting long-term cellular energy production—34% more effective than comparable products.
Autophagy Regulation
It restores cell homeostasis by modulating autophagy, reducing premature aging and oxidative stress by over 27% better than alternatives.
Inflammation Suppression
With a 50% improvement in suppressing pro-inflammatory factors like TNF-α and 42.64% neutrophil inhibition, HydroHA is ideal for sensitive, stressed, or post-treatment skin.
Formulation Benefits
HydroHA is not only clinically powerful — it’s also formulator-friendly:
-
High water solubility with a low-viscosity profile
-
Stable at various pH ranges, making it versatile across skincare formats
-
INCI: Hydrolyzed Sodium Hyaluronate — compliant and widely accepted
Recommended inclusion rates range from 0.05%–0.15% depending on desired effects and product type.
Real Results, Backed by Data
✔ 77% boost in Type I Collagen gene expression → Anti-wrinkle & firming
✔ Higher tetrasaccharide (HA4) & hexasaccharide (HA6) content → Improved skin affinity
✔ Superior cellular fusion ability → Faster and deeper endocytosis of actives
These results aren’t theoretical. They are backed by rigorous lab testing, comparative trials against leading competitive ingredients, and ongoing feedback from formulators around the globe.
Applications Across Cosmetic Innovation
HydroHA (800Da) is ideal for:
-
Anti-aging serums and creams targeting fine lines and elasticity
-
Post-procedure recovery formulas for accelerated skin healing
-
Soothing products for sensitive skin needing high-efficacy with low irritation
-
Hydration boosters that work from the inside-out
HydroHA — A Future-Ready Ingredient
In a market where consumers demand performance, science-backed results, and clean-label transparency, HydroHA delivers across all fronts.
This isn’t just another hyaluronic acid — it’s a next-gen bioactive that offers clinical efficacy in low doses, cell-level rejuvenation, and a technological edge over existing HA products on the market.
For technical documents, samples, or formulation support, contact us, or speak directly to your account manager.
Unifect Ltd — Uniquely, Effective Ingredients.
Written by
Paul Teasdale
General Manager
Unifect Ltd